Search results for "pleiotropic effect"
showing 3 items of 3 documents
Exenatide prevents statin-related LDL receptor increase and improves insulin secretion in pancreatic beta cells (1.1E7) in a protein kinase A-depende…
2022
Statins are primary drugs in the treatment of hyperlipidemias. This group of drugs is known for its beneficial pleiotropic effects (e.g., reduction of inflammatory state). However, a growing body of evidence suggests its diabetogenic properties. The culpable mechanism is not completely understood and might be related to the damage to pancreatic beta cells. Therefore, we conceived an in vitro study to explore the impact of atorvastatin on pancreatic islet beta cells line (1.1.E7). We evaluated the influence on viability, insulin, lowdensity lipoprotein (LDL) receptor, and proprotein convertase subtilisin/kexin type 9 (PCSK9) expression. A significant drop in mRNA for proinsulin and insulin e…
Atorvastatin in stable angina patients lowers CCL2 and ICAM1 expression: Pleiotropic evidence from plasma mRNA analyses
2013
Objective: Statin pleiotropy is still an evolving concept, and the lack of clarity on this subject is due at least in part to the lack of a definitive biomarker for statin pleiotropy. Using plasma mRNA analysis as a novel research tool for the non-invasive in vivo assessment of gene expression in vascular beds, we hypothesised that atorvastatin lowers the plasmamRNA level from statin pleiotropy-target genes, and the reduction is independent of the reduction of low-density lipoprotein cholesterol (LDL-C). Design and methods: Forty-four patients with stable angina received atorvastatin therapy (20 mg/day, 10 weeks). Plasma chemokine (C-C motif) ligand 2 (CCL2) and intercellular adhesion molec…
Mutant ACCase alleles endowing herbicide resistance have a direct effect on seed germination
2013
Germination and emergence dynamics and herbicide resistance are adaptive traits crucial for weed persistence in arable fields. Herbicide resistance alleles can have pleiotropic effects on other traits. We investigated the pleiotropic effects of acetyl-coenzyme A carboxylase (ACCase) alleles L1781, N2041 or G2078 on seed germination and seedling emergence in the grass weed Alopecurus myosuroides (black-grass). We used black-grass populations with homogenised genetic backgrounds that segregated for L1781, N2041 or G2078 ACCase alleles. In two series of experiments, germination dynamics and seedling growth were compared among seeds containing embryos carrying no, one or two copies of a given m…